Key result
In patients with patent foramen ovale and cryptogenic stroke, annual stroke recurrence rates were low and comparable between transcatheter closure (2.9%/year) and medical therapy (2.1%/year).
Why the study?
Does transcatheter or surgical PFO closure reduce recurrent ischemic events compared to medical therapy in patients with cryptogenic cerebral ischemia and PFO?
Population
124 patients with cryptogenic cerebral ischemia and a patent foramen ovale, mean age 51 +/- 15 years.
Comparison
Transcatheter closure or surgical closure of the… vs Medical therapy or no medication.
Design
Cohort
Follow-up
mean 52 +/- 32 months
Authors
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Recurrence rates low and similar with medical therapy or closure; leaves optimal strategy open pending definitive RCTs.
Observational (n=124)
Yes
Does transcatheter or surgical PFO closure reduce recurrent ischemic events compared to medical therapy in patients with cryptogenic cerebral ischemia and PFO?
Absolute Event Rate: 2.9% vs 2.1%
p-value: p=>0.05
In patients with cryptogenic stroke and PFO, the absolute risk of recurrent cerebrovascular events is low and comparable between medical therapy and transcatheter closure in this observational cohort.
Harrer et al. (2006) conducted an observational in Cryptogenic cerebral ischemia and patent foramen ovale (n=124). Transcatheter closure vs. Medical therapy was evaluated on Annual recurrence rate of cerebral ischemic events (p=>0.05). In patients with patent foramen ovale and cryptogenic stroke, annual stroke recurrence rates were low and comparable between transcatheter closure (2.9%/year) and medical therapy (2.1%/year).
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