What is the clinical evidence from this study?

Study design: Case Report. Population: Atrial right-to-left shunting with severe hypoxaemia and normal right-sided pressures (n=11). Intervention: Percutaneous closure of the inter-atrial defect. Primary outcome: Successful treatment by percutaneous closure.

What question did this study set out to answer?

The study aims to evaluate the incidence of hypoxaemia caused by right-to-left shunting despite normal right-sided pressures and its treatment outcomes.

March 15, 2000European Heart JournalOpen Access

Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. Report of 11 consecutive cases corrected by percutaneous closure

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Key result

Percutaneous closure of inter-atrial defects successfully treated hypoxemia in 10 of 11 patients with right-to-left shunting and normal right-sided pressures, with no desaturation up to 30 months.

Why the study?

Does percutaneous closure correct hypoxaemia in patients with atrial right-to-left shunting and normal right-sided pressures?

Population

11 consecutive adult patients with a patent foramen ovale or small atrial septal defect, normal right-sided…

Design

Case_series

Follow-up

up to 30 months

Authors

FGFrançois GodartCentre Hospitalier Universitaire de Lille

Discussion

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Implication

Raises awareness for PFO-related cyanosis without PH; hypothesis-generating and requires prospective confirmation before practice change.

Key Points

The study aims to evaluate the incidence of hypoxaemia caused by right-to-left shunting despite normal right-sided pressures and its treatment outcomes.
11 consecutive patients aged 59-78 years with right-to-left shunting were assessed.
Diagnosis confirmed by contrast transoesophageal echocardiography.
Patients underwent percutaneous closure of the inter-atrial defect.
Successful treatment achieved in 10 out of 11 patients, with one occluder delivery failure due to sheath kinking.
Four complications occurred: two supraventricular arrhythmias and one cerebrovascular accident, all resolved.
No episodes of desaturation related to shunting during follow-up of up to 30 months.

Study Design

Type

Case Report (n=11)

Structured PICO

Does percutaneous closure correct hypoxaemia in patients with atrial right-to-left shunting and normal right-sided pressures?

Population

11 consecutive patients aged 59-78 years with significant cyanosis due to an atrial right-to-left shunt and normal right-sided pressures, followed for up to 30 months.

Intervention

Percutaneous closure of the inter-atrial defect

Outcome

Correction of hypoxaemia and prevention of desaturation episodes

Percutaneous closure of inter-atrial defects is an effective and rapid treatment for severe hypoxaemia caused by right-to-left shunting in patients with normal right-sided pressures.

Cite This Study

François Godart (2000) conducted a case report in Atrial right-to-left shunting with severe hypoxaemia and normal right-sided pressures (n=11). Percutaneous closure of the inter-atrial defect was evaluated on Successful treatment by percutaneous closure. Percutaneous closure of inter-atrial defects successfully treated hypoxemia in 10 of 11 patients with right-to-left shunting and normal right-sided pressures, with no desaturation up to 30 months.

synapsesocial.com/papers/6a6bf9b534b735385cb3dc97 https://doi.org/10.1053/euhj.1999.1944

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Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. Report of 11 consecutive cases corrected by percutaneous closure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. Report of 11 consecutive cases corrected by percutaneous closure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

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