Estimation of Global Left Ventricular Function from the Velocity of Longitudinal Shortening
Key result
Pulsed-wave Doppler myocardial imaging of mitral annular motion correlated with radionuclide ejection fraction (r=0.55 for medial, r=0.54 for lateral; P<0.001).
Why the study?
Does pulsed-wave Doppler myocardial imaging of mitral annular motion accurately estimate global left ventricular function compared to radionuclide ventriculography?
Population
51 patients with a radionuclide ejection fraction of 52 +/- 13%
Comparison
Pulsed-wave Doppler myocardial imaging of mitral… vs Radionuclide ventriculography (reference standard)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Mitral annular velocities correlate only modestly with EF; leaves open their role as a reliable echocardiographic surrogate pending larger validation studies.
Study Design
Type
Cross-Sectional (n=51)
Structured PICO
Does pulsed-wave Doppler myocardial imaging of mitral annular motion accurately estimate global left ventricular function compared to radionuclide ventriculography?
P
Population
51 patients (mean age 56, 22% female) with a mean radionuclide ejection fraction of 52%.
E
Exposure
Pulsed-wave Doppler myocardial imaging of mitral annular motion
C
Comparator
Radionuclide ventriculography (reference standard)
O
Outcome
Correlation between peak systolic velocities and time-velocity integrals of mitral annular motion and radionuclide ejection fractionsurrogate
Main Result
Effect estimate: Correlation 0.55 (medial) and 0.54 (lateral)
p-value: p=< 0.001
Pulsed-wave Doppler myocardial imaging of mitral annular velocity provides a simple and clinically useful estimate of global left ventricular systolic function, particularly in patients without regional wall-motion abnormalities.
Limitations
- In patients with important segmental wall-motion abnormalities during systole, left ventricular longitudinal shortening is an imperfect surrogate for ejection fraction.
- Imperfect surrogate for ejection fraction in patients with important segmental wall-motion abnormalities during systole
Cite This Study
Vinereanu et al. (2002) conducted a cross-sectional in Left ventricular function assessment (n=51). Pulsed-wave Doppler myocardial imaging of mitral annular motion vs. Radionuclide ventriculography was evaluated on Correlation of peak systolic velocities of mitral annular motion with ejection fraction (Correlation 0.55 (medial) and 0.54 (lateral), p=< 0.001). Pulsed-wave Doppler myocardial imaging of mitral annular motion correlated with radionuclide ejection fraction (r=0.55 for medial, r=0.54 for lateral; P<0.001).