Key result
Protease inhibitors do not appear to independently predispose HIV-infected patients to QT interval prolongation, though other clinical risk factors may increase the risk.
Why the study?
Do protease inhibitors cause QT interval prolongation and torsade de pointes in HIV-infected patients?
Population
HIV-infected patients and healthy volunteers
Design
Review
Authors
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May reassure against routine QT monitoring for protease inhibitors in HIV; leaves open contributions of other clinical risk factors.
Do protease inhibitors cause QT interval prolongation and torsade de pointes in HIV-infected patients?
Protease inhibitors do not independently cause QT prolongation, suggesting routine ECG monitoring is unnecessary unless patients have multiple risk factors.
Hunt et al. (2011) conducted a review in HIV infection. Protease inhibitors was evaluated on QT interval prolongation and risk for torsade de pointes. Protease inhibitors do not appear to independently predispose HIV-infected patients to QT interval prolongation, though other clinical risk factors may increase the risk.
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