Key result
Administration of ciprofloxacin or levofloxacin did not significantly prolong the mean or longest QTc interval over baseline in patients without concurrent risk factors.
Why the study?
Do ciprofloxacin and levofloxacin prolong the QTc interval in patients receiving these antibiotics?
Observational (n=38)
Do ciprofloxacin and levofloxacin prolong the QTc interval in patients receiving these antibiotics?
Ciprofloxacin and levofloxacin do not cause significant QTc prolongation in patients without concurrent risk factors such as electrolyte deficiencies.
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Supports QTc safety of these agents without risk factors; hypothesis-generating and requires randomized confirmation before changing practice.
Makaryus et al. (2006) conducted an observational in Infection requiring fluoroquinolone therapy (n=38). Ciprofloxacin or levofloxacin vs. Baseline (pre-administration) was evaluated on Change in longest and mean QTc interval. Administration of ciprofloxacin or levofloxacin did not significantly prolong the mean or longest QTc interval over baseline in patients without concurrent risk factors.
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