Key result
Single high doses of moxifloxacin increased the QTc interval by 16.34 to 17.83 ms (P<0.001 vs placebo), which was consistently greater than the increases with levofloxacin or ciprofloxacin.
Why the study?
Do single high doses of levofloxacin, moxifloxacin, and ciprofloxacin increase the QT and QTc interval compared to placebo in healthy adults?
RCT
Double-blind
Crossover
Do single high doses of levofloxacin, moxifloxacin, and ciprofloxacin increase the QT and QTc interval compared to placebo in healthy adults?
p-value: p=< .001
Single high doses of moxifloxacin cause significantly greater QTc prolongation compared to levofloxacin or ciprofloxacin in healthy adults.
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High-dose moxifloxacin warrants greater QTc caution than levofloxacin or ciprofloxacin; confirms differential effects in RCT.
Gary J. Noel (2003) conducted an RCT in Healthy adults. Levofloxacin, moxifloxacin, and ciprofloxacin vs. Placebo was evaluated on Changes in QT and QTc interval from baseline (p=< .001). Single high doses of moxifloxacin increased the QTc interval by 16.34 to 17.83 ms (P<0.001 vs placebo), which was consistently greater than the increases with levofloxacin or ciprofloxacin.
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