Key result
Single high doses of moxifloxacin increased the QTc interval by 16.34 to 17.83 ms (P<0.001 vs placebo), which was consistently greater than the increases with levofloxacin or ciprofloxacin.
Why the study?
Do single high doses of levofloxacin, moxifloxacin, and ciprofloxacin increase the QT and QTc interval compared to placebo in healthy adults?
Population
Healthy adult volunteers
Comparison
Single doses of 1000 mg levofloxacin, 800 mg… vs Placebo
Design
RCT, randomized, 4-period, 4-treatment, 4-sequence crossover, double-blind
Follow-up
24 hours
Authors
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High-dose moxifloxacin warrants greater QTc caution than levofloxacin or ciprofloxacin; confirms differential effects in RCT.
RCT
Double-blind
Crossover
Do single high doses of levofloxacin, moxifloxacin, and ciprofloxacin increase the QT and QTc interval compared to placebo in healthy adults?
p-value: p=< .001
Single high doses of moxifloxacin cause significantly greater QTc prolongation compared to levofloxacin or ciprofloxacin in healthy adults.
Gary J. Noel (2003) conducted an RCT in Healthy adults. Levofloxacin, moxifloxacin, and ciprofloxacin vs. Placebo was evaluated on Changes in QT and QTc interval from baseline (p=< .001). Single high doses of moxifloxacin increased the QTc interval by 16.34 to 17.83 ms (P<0.001 vs placebo), which was consistently greater than the increases with levofloxacin or ciprofloxacin.
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