Sudden Deaths in Psychiatric Patients
Key result
First- and second-generation antipsychotic use was not associated with unexplained sudden deaths in psychiatric patients, whereas comorbid dyslipidemia and diabetes were more common (P=0.006).
Why the study?
Are unexplained sudden deaths in psychiatric patients associated with higher utilization of antipsychotics compared to explained sudden deaths?
Population
100 adults with sudden death receiving care in one large psychiatric hospital in New York over a 26-year…
Comparison
Unexplained sudden death (n=52) vs Explained sudden death (n=48)
Design
Cohort
Follow-up
26-year period (1984-2009)
Authors
Discussion
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Implication
Unexplained sudden deaths in psychiatric patients appear to be associated with metabolic risk factors like diabetes and dyslipidemia rather than the use of antipsychotic medications.
Study Design
Type
Cohort (n=100)
Multicenter
No
Structured PICO
Are unexplained sudden deaths in psychiatric patients associated with higher utilization of antipsychotics compared to explained sudden deaths?
P
Population
100 adult psychiatric patients who experienced sudden death over a 26-year period in a New York hospital, analyzed to compare explained versus unexplained cases.
E
Exposure
Unexplained sudden death (n=52)
C
Comparator
Explained sudden death (n=48)
O
Outcome
Association with clinical variables and utilization of first- and second-generation antipsychoticshard clinical
Unexplained sudden deaths in psychiatric patients appear to be associated with metabolic risk factors like diabetes and dyslipidemia rather than the use of antipsychotic medications.
Cite This Study
Manu et al. (2011) conducted a cohort in Psychiatric patients (n=100). First- and second-generation antipsychotics vs. Non-users was evaluated on Utilization of first- or second-generation antipsychotics in unexplained versus explained sudden death cases. First- and second-generation antipsychotic use was not associated with unexplained sudden deaths in psychiatric patients, whereas comorbid dyslipidemia and diabetes were more common (P=0.006).