Key result
58Co-EDTA demonstrated a myocardial volume of distribution of 0.294 ml/g, comparable to 0.303 ml/g for [14C]sucrose, indicating it is a useful gamma-labeled marker for extracellular fluid space.
Population
Intact rabbits (2 hearts, n=130 samples) and isolated rabbit interventricular septum (n=16)
Comparison
58Co-EDTA as an extracellular fluid space marker vs [14C]sucrose
Design
Preclinical
Authors
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58Co-EDTA may enable gamma-based myocardial extracellular volume assessment in research; leaves open clinical validation.
Effect estimate: ratio 0.973
Absolute Event Rate: 0.294% vs 0.303%
58Co-EDTA is a stable, biologically inert gamma-labeled marker that accurately measures extracellular fluid space in the myocardium, comparable to [14C]sucrose.
Bridge et al. (1982) studied this question. 58Co-EDTA vs. [14C]sucrose was evaluated on Volume of distribution in the myocardium (ratio 0.973). 58Co-EDTA demonstrated a myocardial volume of distribution of 0.294 ml/g, comparable to 0.303 ml/g for [14C]sucrose, indicating it is a useful gamma-labeled marker for extracellular fluid space.
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