Population
Isolated blood-perfused rabbit interventricular septa
Comparison
Global ischemia induced by enclosure in a… vs Different temperatures and ion concentrations
Design
Preclinical
Follow-up
10 minutes of ischemia followed by reperfusion
Authors
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Hypothesis-generating for ion compartment dynamics in reperfusion; clinical translation requires human trials and should not alter practice.
The study suggests that depletion and/or repletion of single compartments act as rate-limiting steps in myocardial ischemia and reperfusion.
Shine et al. (1976) studied this question.
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