Key result
Simvastatin administration at 40 mg/day significantly reduced the number of promegakaryocytes in porcine bone marrow compared to control over 56 days (p<0.05), suggesting suppression of thrombopoiesis.
Why the study?
Statins are commonly used to lower serum cholesterol, but their effect on thrombopoiesis needed investigation in a porcine model.
Population
32 pigs
Comparison
Simvastatin 40 mg per day vs control
Design
Randomized animal study
Follow-up
56 days
Authors
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Alerts to possible hematologic effects of simvastatin; animal data leave open human translation.
RCT (n=32)
Randomly divided
No
Absolute Event Rate: 0.104% vs 0.131%
p-value: p=<0.05
Snarska et al. (2019) conducted an RCT in Clinically healthy (n=32). Simvastatin vs. Placebo was evaluated on Number of promegakaryocytes per 1,000 bone marrow cells at day 56 (p=<0.05). Simvastatin administration at 40 mg/day significantly reduced the number of promegakaryocytes in porcine bone marrow compared to control over 56 days (p<0.05), suggesting suppression of thrombopoiesis.
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