Key result
Simvastatin, atorvastatin, fluvastatin and pravastatin reduced platelet activity after 1, 2, 3 and 4 weeks of treatment, respectively (P<0.001, P<0.001, P<0.01, P<0.05).
Why the study?
Do different statins have a time-dependent effect on platelet function in hypercholesterolaemic subjects?
Population
64 hypercholesterolaemic subjects, mean age 48.7 +/- 13.4 years, baseline LDL-C 5.13 +/- 0.23 mmol L-1.
Design
Cohort
Follow-up
one month
Authors
Loading...
Should not yet alter statin choice; leaves open whether time-dependent platelet effects improve outcomes.
Do different statins have a time-dependent effect on platelet function in hypercholesterolaemic subjects?
Different statins reduce platelet activity at varying time points, with the early antiplatelet effect appearing to be related to interference with platelet-associated ox-LDL rather than LDL-C reduction.
Puccetti et al. (2002) studied Hypercholesterolaemia (n=64). Statins (simvastatin, atorvastatin, fluvastatin, pravastatin) was evaluated on Platelet activity. Simvastatin, atorvastatin, fluvastatin and pravastatin reduced platelet activity after 1, 2, 3 and 4 weeks of treatment, respectively (P<0.001, P<0.001, P<0.01, P<0.05).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: