Why the study?
Does atorvastatin reduce platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients?
Population
96 subjects: 48 hypercholesterolaemic subjects requiring statin treatment after an ineffective diet regimen…
Comparison
Atorvastatin 20 mg/day for 9 days vs Baseline values and 48 normal controls
Design
Cohort
Follow-up
9 days
Authors
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Atorvastatin may rapidly reduce platelet oxidized-LDL receptor expression before LDL lowering; hypothesis-generating and requires randomized confirmation before clinical adoption.
Does atorvastatin reduce platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients?
Atorvastatin rapidly reduces platelet activation and oxidized-LDL receptor expression before significant cholesterol lowering occurs, suggesting early pleiotropic antiatherothrombotic effects.
Puccetti et al. (2005) studied this question.
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