Key result
Simvastatin and atorvastatin significantly reduced the expression of VCAM-1 and uPAR on endothelial cells (p<0.05) and CD40L on platelets (p<0.005) in an in vitro model.
Population
In vitro model using human umbilical vein endothelial cells (HUVECs) and platelets
Comparison
Simvastatin or atorvastatin for 24 hours vs No statin pre-incubation (control)
Design
Preclinical
Authors
Loading...
Supports statin pleiotropy in vitro; hypothesis-generating and should not change practice.
p-value: p=< 0.05
Simvastatin and atorvastatin demonstrate pleiotropic anti-inflammatory effects by reducing VCAM-1, uPAR, and CD40L expression in an in vitro model of endothelial cells and platelets.
Stach et al. (2012) studied Atherosclerosis. Simvastatin and atorvastatin was evaluated on Expression of VCAM-1 and uPAR on endothelial cells and platelet surface expression of CD40L (p=< 0.05). Simvastatin and atorvastatin significantly reduced the expression of VCAM-1 and uPAR on endothelial cells (p<0.05) and CD40L on platelets (p<0.005) in an in vitro model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: