Why the study?
Does atorvastatin reduce COX-2 gene expression in endothelial cells induced by activated platelets?
Population
Human umbilical vein endothelial cells (HUVEC) and activated platelets
Comparison
Atorvastatin co-incubated with platelets vs Activated platelets without atorvastatin
Design
Preclinical
Authors
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Atorvastatin's platelet effects merit clinical investigation; leaves open translation of this in vitro model to human outcomes.
Does atorvastatin reduce COX-2 gene expression in endothelial cells induced by activated platelets?
Atorvastatin demonstrates pleiotropic anti-inflammatory effects by reducing CD40L-dependent platelet-endothelial interactions and subsequent COX-2 expression.
Mosheimer et al. (2005) studied this question.
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