Key result
In anaesthetized dogs, the vasomotor response elicited by combined stimulation of the carotid sinus and aortic arch baroreceptors was greater than either response resulting from separate stimulation.
This preclinical study demonstrates that combined stimulation of carotid and aortic baroreceptors produces a greater vasomotor response than separate stimulation, and that pulsatile pressure differentially affects these two reflexogenic areas.
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Highlights potential synergy for baroreflex therapies; leaves open translation from dogs to humans.
James et al. (1970) studied Anaesthetized dogs (animal model). Separate and combined stimulation of carotid sinus and aortic arch baroreceptors by pulsatile and non-pulsatile pressures vs. Separate stimulation or non-pulsatile pressures was evaluated on Reflex reduction in systemic vascular resistance. In anaesthetized dogs, the vasomotor response elicited by combined stimulation of the carotid sinus and aortic arch baroreceptors was greater than either response resulting from separate stimulation.
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