Why the study?
Does pulsatile pressure compared to static pressure cause greater inhibition of sympathetic nerve activity in a canine model?
Population
11 dogs anesthetized with chloralose, with isolated carotid sinuses and cut vagosympathetic trunks
Comparison
Pulsatile pressure applied to carotid sinuses… vs Static pressure applied to carotid sinuses over…
Design
Preclinical
Authors
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Should not change clinical baroreflex strategies; leaves open translation of pulsatile advantages to human sympathetic modulation.
Does pulsatile pressure compared to static pressure cause greater inhibition of sympathetic nerve activity in a canine model?
Pulsatile activation of baroreceptors causes greater and more sustained central inhibition of sympathetic nerve activity compared to static activation.
Chapleau et al. (1989) studied this question.
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