Key result
Changes in external pH, rather than P(CO2) or bicarbonate per se, were primarily associated with alterations in resting potential, conduction velocity, and contractions in isolated rabbit atria.
Population
Isolated rabbit atria
Comparison
Exposure to varying concentrations of… vs Comparisons across different pH, P, and…
Design
Preclinical
Authors
Loading...
External pH effects on rabbit atrial electrophysiology warrant caution in clinical translation; leaves open human applicability.
Changes in cardiac muscle contraction and electrophysiology are primarily driven by external pH rather than P(CO2) or bicarbonate levels.
Williams et al. (1967) studied Isolated rabbit atria. Varying bicarbonate and CO2 concentrations (pH changes) vs. Comparison among four sets of conditions (HH, LL, HL, LH) was evaluated on Contractions, conduction velocity, and intracellular potential. Changes in external pH, rather than P(CO2) or bicarbonate per se, were primarily associated with alterations in resting potential, conduction velocity, and contractions in isolated rabbit atria.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: