Key result
Atrial pacing in patients with coronary artery disease induced angina and shifted mean myocardial lactate extraction from 14.1% during the control period to -15.1% during the pacing period.
Why the study?
Does atrial pacing induce sequential alterations in myocardial lactate metabolism, S-T segments, and left ventricular function in patients with coronary artery disease?
Population
21 patients with coronary artery disease
Comparison
Atrial pacing to induce angina vs Control period (before pacing)
Design
Cohort
Authors
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Pacing-induced lactate production may signal ischemia in CAD; hypothesis-generating and should not yet change practice.
Observational (n=21)
Does atrial pacing induce sequential alterations in myocardial lactate metabolism, S-T segments, and left ventricular function in patients with coronary artery disease?
Absolute Event Rate: -15.1% vs 14.1%
Pacing-induced angina in patients with coronary artery disease is preceded by early, measurable abnormalities in myocardial lactate metabolism, S-T segment depression, and left ventricular impairment.
Parker et al. (1997) conducted an observational in Coronary artery disease (n=21). Atrial pacing vs. Control period (before pacing) was evaluated on Mean myocardial lactate extraction. Atrial pacing in patients with coronary artery disease induced angina and shifted mean myocardial lactate extraction from 14.1% during the control period to -15.1% during the pacing period.
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