Key result
Apixaban treatment led to complete resolution of an intra-atrial thrombus after 3 weeks in a patient who developed the thrombus despite previous warfarin therapy.
Why the study?
Does apixaban resolve intra-atrial thrombus in a patient with atrial fibrillation previously treated with warfarin?
Case Report (n=1)
Does apixaban resolve intra-atrial thrombus in a patient with atrial fibrillation previously treated with warfarin?
Apixaban may be an effective treatment for resolving intra-atrial thrombus in patients with atrial fibrillation who develop thrombi despite prior warfarin therapy.
May support apixaban for warfarin-refractory thrombi in AF; leaves open need for prospective trials before practice change.
OBJECTIVE: To highlight the usefulness of apixaban on intra-atrial thrombus that develops after previous treatment with warfarin. CLINICAL PRESENTATION AND INTERVENTION: A 69-year-old woman with a history of atrial fibrillation treated with warfarin presented with acute decompensated heart failure due to an episode of atrial fibrillation. Transesophageal echocardiogram revealed the presence of an intra-atrial thrombus. She was treated with apixaban, and transesophageal echocardiogram showed complete resolution of the thrombus after 3 weeks of treatment. CONCLUSION: This case highlights the usefulness of apixaban in the management of atrial fibrillation and proven intra-atrial thrombus.
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Valero et al. (2016) conducted a case report in Intra-atrial thrombus and atrial fibrillation (n=1). Apixaban was evaluated on Resolution of intra-atrial thrombus. Apixaban treatment led to complete resolution of an intra-atrial thrombus after 3 weeks in a patient who developed the thrombus despite previous warfarin therapy.
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