Key result
TGF-beta and coculture with endothelial cells significantly inhibited basal and TNF-alpha-induced VCAM-1 expression on human vascular smooth muscle cells.
Population
Cultured human saphenous vein vascular smooth muscle cells and human umbilical vein endothelial cells
Comparison
Cytokine stimulation and coculture with… vs Basal conditions or absence of coculture
Design
Preclinical
Authors
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May implicate TNF-alpha in plaque inflammation; leaves open therapeutic targeting in humans.
Endothelial cells and TGF-beta inhibit VCAM-1 expression on vascular smooth muscle cells, suggesting that loss of endothelial contact in atheroma may promote VCAM-1 expression and vascular lesion propagation.
Gamble et al. (1995) studied Atheroma. TGF-beta and endothelial cell coculture vs. Basal or TNF-alpha stimulated cells alone was evaluated on VCAM-1 expression. TGF-beta and coculture with endothelial cells significantly inhibited basal and TNF-alpha-induced VCAM-1 expression on human vascular smooth muscle cells.
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