Key result
Pulsed-field ablation using a lattice-tip catheter produces acute low-voltage areas that may represent both irreversible myocardial injury and transient tissue stunning.
Why the study?
The relationship between acute voltage reduction after pulsed-field ablation and irreversible tissue injury remains incompletely understood.
Acute low-voltage areas observed immediately after pulsed-field ablation may represent transient tissue stunning or reversible electroporation rather than irreversible injury.
Acute low-voltage areas after PFA may include reversible injury; leaves open whether immediate mapping accurately defines permanent lesions.
Pulsed-field (PF) ablation produces myocardial injury primarily through electroporation.1,2 Although acute voltage reduction after PF application is commonly interpreted as evidence of lesion formation, the relationship between acute voltage reduction and irreversible tissue injury remains incompletely understood. An acute low-voltage area observed immediately after PF ablation (PFA) may include not only irreversibly injured myocardium, but also transiently affected tissue related to reversible electroporation or tissue stunning.
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Fukaya et al. (2026) studied Myocardial injury after pulsed-field ablation. Pulsed-field ablation using a lattice-tip catheter was evaluated. Pulsed-field ablation using a lattice-tip catheter produces acute low-voltage areas that may represent both irreversible myocardial injury and transient tissue stunning.
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