Key result
Plasma concentrations of MMP-7 were increased, whereas MMP-2 and -3 were decreased, in patients with stable and unstable coronary artery disease compared to healthy controls.
Why the study?
Do plasma concentrations of MMPs and TIMP-1 differ between patients with coronary artery disease and healthy controls?
Population
65 men with angiographically verified CAD (45 with stable and 20 with unstable CAD) and 28 healthy controls
Design
Case-control
Authors
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Plasma MMP-7 and TIMP-1 elevations may signal CAD instability; leaves open biomarker utility pending prospective validation.
Case-Control (n=93)
Do plasma concentrations of MMPs and TIMP-1 differ between patients with coronary artery disease and healthy controls?
Plasma concentrations of specific MMPs and TIMP-1 are differentially regulated in coronary artery disease and may serve as biomarkers for the condition and plaque instability.
Nilsson et al. (2006) conducted a case-control in Coronary Artery Disease (n=93). Coronary artery disease vs. Healthy controls was evaluated on Plasma concentrations of matrix metalloproteinases (MMPs) and TIMP-1. Plasma concentrations of MMP-7 were increased, whereas MMP-2 and -3 were decreased, in patients with stable and unstable coronary artery disease compared to healthy controls.
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