Key result
Acute inflammation induced by typhoid vaccination lowered mean arterial pressure and central augmentation index (p<0.05), but did not alter central hemodynamic responses to a sympathoexcitatory stimulus.
Why the study?
Acute inflammation increases cardiovascular risk, causes vasodilation, and impairs vascular sensitivity to sympathetic stimuli, which could impact wave reflections and central blood pressure.
Does acute inflammation induced by typhoid vaccination alter central hemodynamics during a mild sympathoexcitatory stimulus in healthy young adults?
Does acute inflammation induced by typhoid vaccination alter central hemodynamics during a mild sympathoexcitatory stimulus in healthy young adults?
Acute inflammation lowers mean pressure and global wave reflections but preserves central hemodynamic control during a mild sympathoexcitatory stimulus in healthy young adults.
Acute inflammation may alter central hemodynamics during sympathoexcitation in young adults; leaves open clinical relevance for CV risk.
Acute inflammation is associated with an increased risk of cardiovascular events. Acute inflammation causes vasodilation and impairs vascular sensitivity to sympathetic stimuli, which could impact wave reflections and central blood pressure. PURPOSE: Determine the effect of acute inflammation on central hemodynamics during a mild sympathoexcitatory stimulus. METHODS: Central hemodynamics were assessed in 22 apparently healthy young adults (12 males, 25.3 ± 4.4 years, 22.8 ± 3.2 kg/m2) before and during a mild sympathoexcitatory stimulus (-20 mmHg lower body negative pressure [LBNP]) at baseline and 24h following a typhoid vaccination. Central pressure and augmentation index (AIx) were obtained via radial tonometry and a validated generalized transfer function. Aortic pulse wave velocity (PWV) and reflection index were also measured. Measures were calibrated to brachial mean and diastolic pressure measured via oscillometric cuff. C-reactive protein (CRP) and interleukin-6 (IL-6) were assessed via standard ELISA techniques. RESULTS: Acute inflammation was induced with significant increases in IL-6 (1.12 ± 0.53 to 2.38 ± 1.33 pg/mL; p < 0.001) and CRP (1.11 ± 2.03 to 2.81 ± 3.79 mg/L; p = 0.001). No changes were observed for heart rate or pulse wave velocity in response to inflammation. Acute inflammation resulted in reductions in diastolic and mean arterial pressure, and central augmentation index (AIx) (p<0.05), while reflection index was not altered (p > 0.05). There were no effects of LBNP, and no effect of inflammation on LBNP responses (interactions > 0.05). CONCLUSION: Acute inflammation lowered mean pressure as well as global wave reflections, suggesting peripheral vasodilation. Central hemodynamic control during a sympathoexcitatory stimulus is preserved during acute inflammation in young, apparently healthy adults.
No takes yet. Share an insight, caveat, or question.
McMillan et al. (2019) studied Healthy (n=22). Typhoid vaccination (acute inflammation) vs. Baseline (before vaccination) was evaluated on Central hemodynamics during a mild sympathoexcitatory stimulus (lower body negative pressure) (p=>0.05). Acute inflammation induced by typhoid vaccination lowered mean arterial pressure and central augmentation index (p<0.05), but did not alter central hemodynamic responses to a sympathoexcitatory stimulus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: