Key result
Acute cold exposure for 30 minutes significantly increased central aortic augmentation index from 3.4% to 19.4% (P<0.05) and increased central systolic pressure more than brachial pressure.
Why the study?
Does acute cold exposure increase central aortic wave reflection and central pressure in healthy men?
Population
12 apparently healthy men, mean age 27.8 +/- 2.0 years
Comparison
Acute cold exposure (4 degrees C) for 30 minutes vs Temperate conditions (24 degrees C) for 30 minutes
Design
RCT, Studied at random in either temperate or cold conditions
Follow-up
30 minutes
Authors
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Cold exposure may raise undetected central pressure load; extends causal RCT evidence on environmental effects beyond brachial readings.
RCT (n=12)
Randomized
Does acute cold exposure increase central aortic wave reflection and central pressure in healthy men?
Absolute Event Rate: 19.4% vs 3.4%
p-value: p=<0.05
Acute cold exposure significantly increases central aortic wave reflection and central systolic pressure, changes that are underestimated by standard brachial blood pressure measurements.
Edwards et al. (2005) conducted an RCT in Healthy (n=12). Cold exposure vs. Temperate conditions (24 degrees C) was evaluated on Central aortic augmentation index (AI) (p=<0.05). Acute cold exposure for 30 minutes significantly increased central aortic augmentation index from 3.4% to 19.4% (P<0.05) and increased central systolic pressure more than brachial pressure.