Key result
In gonadectomized mice infected with coxsackievirus B3, the XY sex chromosome complement conferred protection against myocarditis compared to the XX complement (P<0.009), whereas no such effect was observed for influenza A virus.
Why the study?
Does sex chromosome complement influence the pathogenesis and immune response to coxsackievirus B3 and influenza A virus in mice?
Population
Wild-type male and female C57BL/6 mice and gonadectomized four core genotypes mice on a C57BL/6 background
Comparison
Infection with coxsackievirus B3 or… vs Comparison between sexes, gonadal status, and…
Design
Preclinical
Authors
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Sex chromosome effects on viral responses in FCG mice warrant human validation; leaves open clinical translation from this animal model.
Does sex chromosome complement influence the pathogenesis and immune response to coxsackievirus B3 and influenza A virus in mice?
p-value: p=<0.009
Sex chromosome complement influences the pathogenicity of coxsackievirus B3, with the XY complement conferring reduced susceptibility compared to XX, but does not affect influenza A virus pathogenesis.
Robinson et al. (2011) studied Coxsackievirus B3 and Influenza A virus infection. Sex chromosome complement (XX vs XY) vs. XX vs XY was evaluated on Myocarditis severity in CVB3 infection (p=<0.009). In gonadectomized mice infected with coxsackievirus B3, the XY sex chromosome complement conferred protection against myocarditis compared to the XX complement (P<0.009), whereas no such effect was observed for influenza A virus.
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