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August 2, 1991European Heart Journal

Molecular probes for detection of persisting enterovirus infection of human heart and their prognostic value

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Key result

Persisting enterovirus RNA in the myocardium, detected by molecular hybridization, is strongly associated with the development of dilated cardiomyopathy and is a predictor of poor prognosis.

Why the study?

Does the detection of persisting enterovirus RNA using molecular probes predict prognosis in patients with dilated cardiomyopathy?

Population

Patients with myocarditis or dilated cardiomyopathy

Design

Review

Authors

LAL. C. ArchardUniversity of LondonNBNeil E. BowlesNorthwestern UniversityLCLouise CunninghamMemorial Sloan Kettering Cancer Center

Discussion

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Implication

May identify high-risk myocarditis patients for monitoring; leaves open whether antivirals alter progression to transplantation.

Structured PICO

Does the detection of persisting enterovirus RNA using molecular probes predict prognosis in patients with dilated cardiomyopathy?

P
Population
Patients with myocarditis or dilated cardiomyopathy
E
Exposure
Molecular hybridization using enterovirus group-specific probes on endomyocardial biopsies
O
Outcome
Detection of persisting enterovirus RNA and its association with prognosis

Detection of persisting enterovirus RNA in the myocardium using molecular probes is a strong predictor of poor prognosis in patients with dilated cardiomyopathy.

Cite This Study

Archard et al. (1991) conducted a review in Myocarditis and dilated cardiomyopathy. Persisting enterovirus RNA was evaluated on Poor prognosis and development of dilated cardiomyopathy. Persisting enterovirus RNA in the myocardium, detected by molecular hybridization, is strongly associated with the development of dilated cardiomyopathy and is a predictor of poor prognosis.

synapsesocial.com/papers/6a6c414e34b735385cb3ecddhttps://doi.org/10.1093/eurheartj/12.suppl_d.56

Topics

Myocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Pathogenesis of Enterovirus-Induced Myocarditis: Virus Persistence and Chronic Inflammation1993 · 89 citations
  2. 2Detection of enteroviruses in endomyocardial biopsy by molecular approach1992 · 53 citations
  3. 3Clinical and prognostic significance of detection of enteroviral RNA in the myocardium of patients with myocarditis or dilated cardiomyopathy.1994 · 274 citations
  4. 4End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response.1989 · 145 citations
  5. 5Serological and molecular evidence of enterovirus infection in patients with end-stage dilated cardiomyopathy.1996 · 48 citations