Association between estimated glucose disposal rate and nephrolithiasis: a propensity score matching study in US adults: results from the National Health and Nutrition Examination Survey 2011–2020

Background The estimated glucose disposal rate (eGDR) is a reliable substitute for insulin resistance markers. However, a thorough assessment targeting the relationship between eGDR and nephrolithiasis (NL) occurrence has not been performed.Methods In total, 31,566 participants from the National Health and Nutrition Examination Survey 2011–2020 were enrolled in our analysis. We performed the weighted multivariable logistic regression to evaluate the correlation between the eGDR and NL history. Restricted cubic spline curves were used to further explore this correlation. We also conducted similar statistical analyses in the population after a 1:1 propensity score matching (PSM). Receiver operating characteristic (ROC) curves were utilized to determine the predictive power of eGDR for the NL history.Results Our analyses revealed a negative relationship between eGDR and the NL history. Subgroup analysis demonstrated that the association was consistent with the significant outcomes in different stratifications. The analysis after PSM still demonstrated that the eGDR level was negatively related to NL history. In ROC analysis, eGDR had a more considerable value of area under the curve (AUC) compared to visceral adiposity index (VAI), triglyceride-glucose (TyG) index, and body mass index (BMI). The AUC values were 0.62 for eGDR, 0.56 for BMI, 0.52 for TyG, and 0.53 for VAI, with all pairwise comparison P-values < 0.001.Conclusions The eGDR was negatively associated with NL history among the United States population aged ≥ 20. Moreover, eGDR had greater predictive power for NL history than VAI, TyG, and BMI.