Key result
Aberrations in the renal endothelin system may lead to sodium and water retention and subsequently to the development of hypertension.
This review highlights the potential pathophysiological role of the intrarenal endothelin system in the development of hypertension through sodium and water retention.
Renal ET aberrations may drive salt retention and hypertension; leaves open ET(B) targeting as therapeutic hypothesis.
The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the body exist in the renal medulla, where it mediates natriuretic and diuretic effects through the ET(B) receptor subtype. It is proposed that aberrations in the renal ET system may lead to sodium and water retention and subsequently to the development of hypertension.
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Abassi et al. (2001) conducted a review in Hypertension. Aberrations in the renal endothelin system was evaluated. Aberrations in the renal endothelin system may lead to sodium and water retention and subsequently to the development of hypertension.
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