Key result
Endothelin-1 influences preglomerular and postglomerular microvascular tone, significantly impacting renal hemodynamics and potentially contributing to renal injury in cardiovascular diseases.
This review highlights the critical role of endothelin-1 in regulating renal microvascular tone and its potential contribution to renal injury in cardiovascular diseases.
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May guide ET-1 targeted therapies in cardiorenal disease; leaves open effects on clinical renal outcomes.
The endothelin (ET) system comprises a family of three isopeptides (ET-1, ET-2, and ET-3)involved in diverse physiological and pathophysiological events. ET-1 is the major renal peptide that exerts its biological activity by binding to ET(A) and ET(B) receptors. Both ET(A) and ET(B) receptors are expressed by renal microvascular smooth muscle cells, where activation causes vasoconstriction. ET(B) receptors are also expressed by microvascular endothelial cells, where activation leads to vasodilator responses. ET-1 influences preglomerular and postglomerular microvascular tone and thus can significantly influence renal hemodynamics. Alteration of renal ET-1 synthesis and receptor expression has been reported in cardiovascular diseases, and could contribute to renal injury by altering renal microvascular reactivity. In this brief review, we will try to summarize what is known about ET control of renal microvascular function.
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Guan et al. (2011) conducted a review in Cardiovascular diseases and renal injury. Endothelin system was evaluated. Endothelin-1 influences preglomerular and postglomerular microvascular tone, significantly impacting renal hemodynamics and potentially contributing to renal injury in cardiovascular diseases.
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