December 1, 2003European Journal of Cardiovascular Prevention & Rehabilitation
Prognostic ability of VE/VCO₂slope calculations using different exercise test time intervals in subjects with heart failure
Key result
VE/VCO2 slope calculated at various exercise time intervals significantly predicted 1-year cardiac-related hospitalization and mortality in heart failure, outperforming peak VO2.
Why the study?
Does the VE/VCO2 slope calculated at sub-maximal exercise intervals predict 1-year hospitalization and mortality better than peak VO2 in heart failure patients?
Population
72 subjects with heart failure, mean age 51.2 years, 44 male and 28 female, mean LVEF 27.0%
Comparison
VE/VCO2 slope calculated from time 0 to 25, 50… vs Peak oxygen consumption (VO2)
Design
Cohort
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
May support submaximal VE/VCO2 slope for risk stratification in heart failure; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Cohort (n=72)
Structured PICO
Does the VE/VCO2 slope calculated at sub-maximal exercise intervals predict 1-year hospitalization and mortality better than peak VO2 in heart failure patients?
P
Population
72 subjects with heart failure (mean age 51.2 years, 39% female) undergoing symptom-limited exercise testing, followed for 1 year.
E
Exposure
VE/VCO2 slope calculated from time 0 to 25, 50, 75 and 100% of exercise time during symptom-limited exercise testing
C
Comparator
Peak oxygen consumption (VO2)
O
Outcome
1-year cardiac-related hospitalization and mortalityhard clinical
The VE/VCO2 slope maintains its prognostic significance for 1-year hospitalization and mortality in heart failure patients regardless of the exercise-test time interval used, making it valuable even with sub-maximal effort.
Cite This Study
Arena et al. (2003) conducted a cohort in Heart failure (n=72). VE/VCO2 slope calculations at different exercise test time intervals vs. Peak oxygen consumption (VO2) was evaluated on 1-year cardiac-related hospitalization and mortality. VE/VCO2 slope calculated at various exercise time intervals significantly predicted 1-year cardiac-related hospitalization and mortality in heart failure, outperforming peak VO2.