Key result
Captopril produced a dose-dependent reduction in human lung fibroblast proliferation and 3H-thymidine incorporation, likely representing a nonspecific sulfhydryl effect rather than ACE inhibition.
Why the study?
Does captopril inhibit proliferation of human lung fibroblasts in culture?
Does captopril inhibit proliferation of human lung fibroblasts in culture?
Captopril inhibits human lung fibroblast proliferation in vitro through a nonspecific sulfhydryl effect rather than ACE inhibition, suggesting a potential mechanism for its antifibrotic activity.
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Provides mechanistic insight into captopril antifibrotic action; leaves open in vivo confirmation and clinical translation.
Nguyễn et al. (1994) studied Human lung fibroblasts in culture. Captopril was evaluated on Fibroblast proliferation and 3H-thymidine incorporation. Captopril produced a dose-dependent reduction in human lung fibroblast proliferation and 3H-thymidine incorporation, likely representing a nonspecific sulfhydryl effect rather than ACE inhibition.
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