Why the study?
Does captopril inhibit the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation?
Population
Mice and regenerating bone marrow cells from mice treated with cytosine arabinoside or 2 Gy…
Design
Preclinical
Follow-up
24 h (in vitro)
Authors
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May allow selective hematoprotection during cytotoxic therapy without affecting leukemia cells; hypothesis-generating for human translation.
Does captopril inhibit the proliferation of primitive haematopoietic cells induced into cell cycle by cytotoxic drug administration or irradiation?
Captopril inhibits the proliferation of primitive haematopoietic cells but not myeloid leukaemia cells, likely mediated by increased levels of the physiological inhibitor AcSDKP.
Chisi et al. (2000) studied this question.
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