What question did this study set out to answer?

The aim is to assess how acute ACE inhibition affects plasma levels of Ac-SDKP, a natural stem cell regulator.

February 1, 1996Journal of Clinical InvestigationOpen Access

Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.

View Full Paper

Ask AI

Bookmark

Why the study?

Does captopril increase plasma levels of Ac-SDKP in healthy subjects?

Key Points

The aim is to assess how acute ACE inhibition affects plasma levels of Ac-SDKP, a natural stem cell regulator.
Double-blind, crossover, placebo-controlled trial with eight healthy subjects.
Single oral dose of 50 mg of captopril administered.
Measurement of Ac-SDKP plasma levels and in vitro hydrolysis.
Captopril treatment resulted in a 5.5-fold increase in plasma Ac-SDKP levels (range: 4-8.5-fold).
Inhibition of [3H]Ac-SDKP hydrolysis by ACE was 90-99% in vitro.
First demonstration of Ac-SDKP hydrolysis by ACE in vivo, confirming its physiological activity.

Structured PICO

Does captopril increase plasma levels of Ac-SDKP in healthy subjects?

Population

n=8 healthy subjects

Intervention

Captopril 50 mg single oral dose

Comparator

Placebo

Outcome

Plasma level of Ac-SDKP and in vitro [3H]Ac-SDKP hydrolysissurrogate

Acute ACE inhibition with captopril significantly increases plasma levels of the hematopoietic stem cell regulator Ac-SDKP, suggesting a physiological role for ACE in stem cell regulation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

ACE inhibition raises plasma Ac-SDKP in healthy subjects; confirms ACE's physiological role in stem cell regulator metabolism.

Cite This Study

Azizi et al. (1996) studied this question.

synapsesocial.com/papers/6a7212495d37378ac1df006b https://doi.org/10.1172/jci118484

View Full Paper

Ask AI

Bookmark

Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider