Key result
Lower serum and intra-cellular magnesium levels on ICU admission were associated with significantly higher cardiovascular complications and mortality compared to normal levels (P < 0.05).
Why the study?
Hypomagnesemia is common among critically ill patients and linked to worse outcomes, but correlations of serum and intra-cellular magnesium concentrations with ICU complications and mortality needed evaluation.
Do low serum and intra-cellular magnesium concentrations correlate with increased morbidity and mortality in critically ill patients?
Cross-Sectional (n=70)
No
Do low serum and intra-cellular magnesium concentrations correlate with increased morbidity and mortality in critically ill patients?
p-value: p=< 0.05
In critically ill patients, magnesium deficiency on ICU admission is associated with higher disease severity, increased cardiovascular complications, and higher mortality.
Low magnesium on ICU admission may aid risk stratification; hypothesis-generating for supplementation trials before practice change.
Backgrounds: Hypomagnesemia is a common electrolyte disturbance among critically ill patient which is associated with increased morbidity and mortality. In this study, correlations between serum and intra-cellular magnesium concentrations at the time of intensive care unit (ICU) admission with ICU complications and mortality were evaluated. Methods: This cross-sectional study included 70 consecutive adult patients admitted to the intensive care unit of a tertiary referral teaching hospital during a six-month period. Serum and intra-cellular magnesium levels were measured on admission. Clinical information, morbidity, and mortality were followed and recorded during ICU stay until discharge or death. Results: On admission, 37.14% of patients suffered hypomagnesemia. Low intra-cellular magnesium level was observed in 44.28% of patients. Cardiovascular complications and mortality were significantly higher in patients with lower serum and intra-cellular magnesium levels when compared to patients with normal levels (P < 0.05). There was a significant correlation between serum magnesium level on ICU admission and Acute Physiology and Chronic Health Evaluation (APACHE II) score (r = ˗0.39, P < 0.001). Conclusion: Particular attention should be reserved to possible prognostic and therapeutic consequences of magnesium depletion in critically ill patients. Magnesium deficiency was associated with a higher APACHE II score on admission, higher cardiovascular complications, and increased mortality.
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Heidari et al. (2020) conducted a cross-sectional in Critically ill patients (n=70). Low serum and intra-cellular magnesium levels vs. Normal serum and intra-cellular magnesium levels was evaluated on Cardiovascular complications and mortality (p=< 0.05). Lower serum and intra-cellular magnesium levels on ICU admission were associated with significantly higher cardiovascular complications and mortality compared to normal levels (P < 0.05).
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