Key result
The etiology of isolated sporadic Wolff-Parkinson-White syndrome remains unknown, despite known familial patterns and genetic associations in WPW with cardiomyopathy.
Case Report (n=2)
This report highlights the unknown etiology of isolated sporadic Wolff-Parkinson-White syndrome, contrasting it with known genetic causes in familial cases with cardiomyopathy.
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Clinicians should avoid assuming genetic etiology in isolated sporadic WPW; leaves open identification of distinct sporadic mechanisms.
Key Teaching Points•Wolff-Parkinson-White (WPW) syndrome with or without cardiomyopathy may be associated with a familial pattern of inheritance.•Several genes have been identified in patients with familial WPW with associated cardiomyopathy, including mutations in the PRKAG2 gene.•However, the etiology of isolated sporadic WPW syndrome remains unknown. •Wolff-Parkinson-White (WPW) syndrome with or without cardiomyopathy may be associated with a familial pattern of inheritance.•Several genes have been identified in patients with familial WPW with associated cardiomyopathy, including mutations in the PRKAG2 gene.•However, the etiology of isolated sporadic WPW syndrome remains unknown.
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Field et al. (2018) conducted a case report in Isolated Wolff-Parkinson-White syndrome (n=2). The etiology of isolated sporadic Wolff-Parkinson-White syndrome remains unknown, despite known familial patterns and genetic associations in WPW with cardiomyopathy.
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