Insulin and Endothelin: An Interplay Contributing to Hypertension Development?
Key result
Insulin-stimulated activation of the endothelin system may play a crucial role in the pathogenesis of hypertension in insulin-resistant states.
Design
Review
Authors
Discussion
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Member takes
Implication
Does not support practice change; leaves open endothelin targeting in insulin-resistant hypertension.
PICO
P
Population
Hypertension in insulin-resistant states
E
Exposure / Comparator
Insulin and endothelin interaction
This review highlights the interplay between insulin resistance and endothelin-1 activation as a key mechanism contributing to hypertension development.
Cite This Study
Sarafidis et al. (2006) conducted a review in Hypertension in insulin-resistant states. Insulin and endothelin interaction was evaluated. Insulin-stimulated activation of the endothelin system may play a crucial role in the pathogenesis of hypertension in insulin-resistant states.