Key result
Anticoagulant therapy successfully resolved aortic mural thrombi in two patients with multiple hypercoagulable factors without recurrent embolic events.
Case Report (n=2)
No
Aortic mural thrombus can occur in non-atherosclerotic aortas of patients with hypercoagulable states and can be successfully managed with anticoagulation.
Supports anticoagulation for aortic mural thrombi in hypercoagulable states; leaves open need for prospective validation.
An aortic mural thrombus (AMT) on a non-atherosclerotic wall is a rare but important cause of arterial thromboembolism. We herein report two cases of AMT in the thoracic aorta. Both showed multiple hypercoagulable factors (case 1: protein S deficiency and positive finding of anti-cardiolipin antibody; case 2: protein C deficiency, gastric cancer, and cisplatin-based chemotherapy) and were successfully treated with anticoagulation. Hypercoagulable states, including malignancy, can influence the formation of AMT; therefore, the accurate assessment of a hypercoagulable condition is necessary when we encounter patients with AMT.
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Yagyu et al. (2018) conducted a case report in Aortic Mural Thrombus (n=2). Anticoagulant therapy was evaluated on Thrombus resolution and absence of recurrent embolic events. Anticoagulant therapy successfully resolved aortic mural thrombi in two patients with multiple hypercoagulable factors without recurrent embolic events.
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