Key result
Excessive delay and configurational change of ventricular responses to atrial premature beats in the dog heart were shown to be due to functional block of the right bundle branch.
Population
Dog heart (open heart preparations)
Comparison
Vagal stimulation, rapid driving frequencies… vs Baseline conditions (slow heart rates)
Design
Preclinical
Authors
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May inform mechanisms of functional aberration in models; leaves open human translation and clinical relevance.
This preclinical study demonstrates that aberrant A-V impulse propagation and functional bundle branch block are primarily due to the refractory period of the right bundle branch exceeding that of the A-V node at slow heart rates.
Moe et al. (1965) studied Functional bundle branch block. Vagal stimulation, rapid driving frequencies, and epinephrine was evaluated on Aberrant A-V impulse propagation and functional block of the right bundle branch. Excessive delay and configurational change of ventricular responses to atrial premature beats in the dog heart were shown to be due to functional block of the right bundle branch.
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