Key result
Ventricular cells exhibited an average of 2.32 overlapping open inward rectifier K channels per patch, compared to 0.03-0.06 in nodal cells, explaining the lower resting K conductance in pacemaker cells.
Absolute Event Rate: 2.32% vs 0.06%
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Channel density markedly lower in rabbit nodal vs ventricular cells; leaves open relevance to human conduction or arrhythmia mechanisms.
Noma et al. (1984) studied Normal cardiac electrophysiology (n=347). Ventricular cells vs. Sinoatrial and atrioventricular node cells was evaluated on Average number of overlaps of open inward rectifier K channels (iK.rec) per patch. Ventricular cells exhibited an average of 2.32 overlapping open inward rectifier K channels per patch, compared to 0.03-0.06 in nodal cells, explaining the lower resting K conductance in pacemaker cells.
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