Key result
The inward rectifier K+ current in rabbit ventricular cells demonstrates time- and voltage-dependent kinetics, with a slope conductance of 46.6 pS and open probability decreasing with hyperpolarization.
Population
Isolated rabbit ventricular cells
Design
Preclinical
Authors
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Does not inform arrhythmia management; leaves open translation of rabbit IK1 kinetics to human models.
The study demonstrates that the inward rectifier K+ channel in mammalian ventricular cells has an inwardly rectifying single-channel I-V relation and voltage-dependent transition kinetics between open and closed states.
Kameyama et al. (1983) studied Rabbit ventricular cells (n=16). Patch-clamp method with varying K+, Cs+, and Ba2+ concentrations was evaluated on Single channel kinetics (slope conductance, open probability, open/closed times). The inward rectifier K+ current in rabbit ventricular cells demonstrates time- and voltage-dependent kinetics, with a slope conductance of 46.6 pS and open probability decreasing with hyperpolarization.
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