Inward-rectifying K+ channels in guinea-pig ventricular cells have a single-channel conductance of 27 pS in symmetrical 145 mM K+ and mediate the resting K+ conductance (IK1).
Inward-rectifying K+ channels mediate the resting K+ conductance of ventricular heart muscle and the IK1 current, with conductance dependent on the square root of external K+ concentration.
Single ventricular cells were enzymatically isolated from adult guinea-pig hearts (Isenberg the average of twenty-eight patches was 1 channel/1.8 micron2. It is concluded that the inward-rectifying K+ channels mediate the resting K+ conductance of ventricular heart muscle and the current termed IK1 in conventional voltage-clamp experiments.
Sakmann et al. (1984) studied this question. Patch-clamp technique was evaluated on Conductance properties of inward-rectifying K+ channels. Inward-rectifying K+ channels in guinea-pig ventricular cells have a single-channel conductance of 27 pS in symmetrical 145 mM K+ and mediate the resting K+ conductance (IK1).