The study demonstrates that the inactivation gate of the myocardial inward rectifier K+ channel has at least two open states, explaining its peculiar transient kinetics after hyperpolarization.
No direct clinical implications; extends animal evidence on myocardial K+ channel gating but leaves human relevance open.
The current through a myocardial inward rectifier K+ channel was recorded by the patch clamp technique. The inactivation gate of the channel has open probability of nearly 1 at the potentials positive to EK and showed peculiar kinetics in the 1st open events after hyperpolarization from these potentials. Analysis of this kinetics suggested two open states in this gate.
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Taniguchi et al. (1984) studied this question.
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