Key result
Low predialysis systolic blood pressure increased mortality in older and diabetic hemodialysis patients, while high systolic blood pressure increased mortality only in younger patients.
Population
16,283 incident hemodialysis patients, 45.9% female, 58.2% white, 35.6% black. 46.6% had ESRD caused by…
Design
Cohort
Follow-up
median 1.5 years
Authors
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Low SBP-mortality link stronger in older and diabetic HD patients; extends effect-modification data but leaves targets open for RCTs.
Cohort (n=16,283)
Yes
The relationship between blood pressure and mortality in hemodialysis patients is highly dependent on age and diabetes status, suggesting that optimal BP targets should be individualized rather than uniformly applied.
Myers et al. (2010) conducted a cohort in End-stage renal disease on hemodialysis (n=16,283). Predialysis systolic blood pressure vs. Reference systolic blood pressure levels (e.g., 140 mmHg) was evaluated on All-cause mortality. Low predialysis systolic blood pressure increased mortality in older and diabetic hemodialysis patients, while high systolic blood pressure increased mortality only in younger patients.
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