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March 26, 2025Academia molecular biology and genomics.Open Access

Exploring Bacillus velezensis in a biomedical context: a systematic review

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Authors

ESEduarda Guimarães SousaUniversidade Federal de Minas GeraisGCGabriela Munis CamposUniversidade Federal do Espírito SantoLQLudmila Silva QuaresmaUniversidade Federal de Minas Gerais

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Implication

Systematic review reveals the therapeutic potential of Bacillus velezensis, highlighting its production of bioactive metabolites like surfactin and fengycin for mammalian probiotic use.

Key Points

  • To synthesize current evidence regarding the biomedical and probiotic potential of Bacillus velezensis in mammalian systems across in vitro and in vivo studies.
  • Systematic search conducted across Dimensions, Scopus, PubMed, and Web of Science through December 10, 2023, following PRISMA guidelines.
  • Identified 1,585 initial records, including 151 studies in scientometric analysis and 13 in vitro and in vivo studies for qualitative synthesis.
  • Identified major bioactive secondary metabolites synthesized by the bacterium, specifically surfactin, bacilysin, and fengycin, which drive antimicrobial and anti-inflammatory activity.
  • Demonstrated mammalian probiotic capability supported by strong pathogen antagonism, lack of transferable antibiotic resistance, and positive immunomodulatory effects.
  • Identified a critical need to optimize laboratory cultivation parameters to regulate gene expression and maximize the yield of active secondary metabolites.

Cite This Study

Sousa et al. (2025) studied this question.

synapsesocial.com/papers/6a6c9bb778a11c550e07950ahttps://doi.org/10.20935/acadmolbiogen7598
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