Key result
Intracoronary injection of veratridine increased myocardial contractility and caused a reflex decrease in mean aortic pressure by 27%, demonstrating that the Bezold reflex is initiated by left ventricular mechanoreceptors.
Why the study?
Does intracoronary injection of positive inotropic agents initiate the Bezold reflex by increasing myocardial contractility in a dog model?
Does intracoronary injection of positive inotropic agents initiate the Bezold reflex by increasing myocardial contractility in a dog model?
p-value: p=<0.05
The Bezold reflex is a special case of the left ventricular mechanoreceptor reflex, initiated by increased myocardial contractility rather than chemoreceptor stimulation.
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LV mechanoreceptor role in Bezold reflex remains experimental; leaves open any clinical relevance or therapeutic targeting.
Estrin et al. (1979) studied Normal physiology (animal model) (n=38). Intracoronary injection of veratrum alkaloids (veratridine) vs. Baseline (pre-injection) was evaluated on Change in mean aortic pressure (% of control) (p=<0.05). Intracoronary injection of veratridine increased myocardial contractility and caused a reflex decrease in mean aortic pressure by 27%, demonstrating that the Bezold reflex is initiated by left ventricular mechanoreceptors.
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