Key result
A review of the mammalian expression pattern of K(IR)2.x subunits reveals correlations between expression and function in muscle and bone tissue, alongside a discrepancy in neuronal tissue.
This review highlights the complex expression patterns of mammalian K(IR)2.x subunits and their functional roles in establishing resting membrane potentials across various excitable tissues.
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Kir2.x channels stabilize resting potential across excitable tissues; extends mutation and inhibition data to human phenotypes but leaves targeted therapies open.
Inward rectifier currents based on K(IR)2.x subunits are regarded as essential components for establishing a stable and negative resting membrane potential in many excitable cell types. Pharmacological inhibition, null mutation in mice and dominant positive and negative mutations in patients reveal some of the important functions of these channels in their native tissues. Here we review the complex mammalian expression pattern of K(IR)2.x subunits and relate these to the outcomes of functional inhibition of the resultant channels. Correlations between expression and function in muscle and bone tissue are observed, while we recognize a discrepancy between neuronal expression and function.
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Boer et al. (2010) conducted a review in K(IR)2.x inward rectifier ion channel function and expression. K(IR)2.x subunits was evaluated. A review of the mammalian expression pattern of K(IR)2.x subunits reveals correlations between expression and function in muscle and bone tissue, alongside a discrepancy in neuronal tissue.
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