Key result
In cultured neonatal mouse cardiac myocytes, depolarization-induced Ca2+ influx triggered whole-cell Ca2+ spikes, whereas sarcoplasmic reticulum Ca2+ release caused propagating Ca2+ waves.
In cultured neonatal mouse ventricular myocytes, Ca2+ spikes are triggered by depolarization-induced Ca2+ influx across the sarcolemma, whereas Ca2+ waves are propagating local increases due to Ca2+ release from the sarcoplasmic reticulum.
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Simultaneous cytoplasmic Ca2+ rise visualized in neonatal myocytes; leaves open relevance to adult human Ca2+ handling and arrhythmias.
Tanaka et al. (1996) studied this question. Tetrodotoxin, nicardipine, increased extracellular potassium, ryanodine, and cyclopiazonic acid was evaluated on Intracellular free Ca2+ movements (spike and wave). In cultured neonatal mouse cardiac myocytes, depolarization-induced Ca2+ influx triggered whole-cell Ca2+ spikes, whereas sarcoplasmic reticulum Ca2+ release caused propagating Ca2+ waves.
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