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June 1, 1993Antimicrobial Agents and ChemotherapyOpen Access

Novel gyrA point mutation in a strain of Escherichia coli resistant to fluoroquinolones but not to nalidixic acid

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Authors

ECEmmanuelle CambauInsermFBF BordonSorbonne UniversitéECE. CollatzUniversité Paris Cité

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Cambau et al. (1993) studied this question.

synapsesocial.com/papers/6a6c9f6ff44fa9f079db50eahttps://doi.org/10.1128/aac.37.6.1247
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins1991 · 95 citations
  2. 2Detection of gyrA gene mutations associated with ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus: analysis by polymerase chain reaction and automated direct DNA sequencing1992 · 105 citations
  3. 3In-vitro activity of newer quinolones against aerobic bacteria1986 · 101 citations
  4. 4Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme1977 · 789 citations
  5. 5DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance1990 · 62 citations