What question did this study set out to answer?

To investigate how carbamylated and acetylated hemoglobins affect glycohemoglobin assays.

Interference of carbamylated and acetylated hemoglobins in assays of glycohemoglobin by HPLC, electrophoresis, affinity chromatography, and enzyme immunoassay

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Randomized trial examines glycohemoglobin assay interference in vitro, highlighting significant impact from carbamylated hemoglobin.

To investigate how carbamylated and acetylated hemoglobins affect glycohemoglobin assays.
In vitro synthesis of carbamylated and acetylated hemoglobins
Assessment of glycohemoglobin assays using HPLC, electrophoresis, affinity chromatography, and enzyme immunoassay
Evaluation of correlations between serum urea concentrations and glycohemoglobin percentages
HPLC and electrophoresis assays showed interference from carbamylated and acetylated hemoglobins
No significant interference observed in affinity chromatography and enzyme immunoassay
0.063% of carbamylated hemoglobin forms for every 1 mmol/L of serum urea.

Weykamp et al. (1993) studied this question.

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