Key result
Primary prophylactic CRT-D was not associated with better long-term survival compared to CRT-P after covariate adjustment, despite unadjusted annual mortality rates of 5.3% vs 11.8%.
Why the study?
Does primary prophylactic CRT-D improve long-term survival compared to CRT-P in patients with heart failure?
Cohort (n=705)
No
Does primary prophylactic CRT-D improve long-term survival compared to CRT-P in patients with heart failure?
Absolute Event Rate: 5.3% vs 11.8%
In a real-world retrospective cohort, primary prophylactic CRT-D was not associated with an independent long-term survival benefit over CRT-P after adjusting for baseline covariates.
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Real-world CRT-D vs CRT-P data warrant caution in device selection; leaves open incremental defibrillator benefit in heart failure.
Reitan et al. (2015) conducted a cohort in Heart failure (n=705). Primary prophylactic CRT-defibrillators (CRT-D) vs. CRT-pacemakers (CRT-P) was evaluated on All-cause mortality. Primary prophylactic CRT-D was not associated with better long-term survival compared to CRT-P after covariate adjustment, despite unadjusted annual mortality rates of 5.3% vs 11.8%.
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